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Below is more scientific research into wines Resveratrol.

The Washington Post, Thursday, June 5, 2008

Red Wine Compound Helps Heart & May Slow Aging

(Health Day News) -- Resveratrol, a compound found in grapes, red wine, pomegranates and certain other foods, may protect the heart and slow the effects of aging, a new study suggests.

Tests in mice revealed that low doses of resveratrol mimic the effects of caloric restriction, diets with 20 percent to 30 percent fewer calories than a typical diet that have been shown to extend life span.

Previous research has shown that high doses of resveratol prevent early death in mice fed a high-fat diet. This new study adds to those findings, showing that receiving low doses of resveratrol in the middle aged offers many of the benefits as a calorie-reduced diet.

"This brings down the dose of resveratrol toward the consumption reality mode. At the same time, it plugs into the biology of caloric restriction," co-senior author Richard Weindruch, a professor of medicine at the University of Wiscon sin-Madison, said in a prepared statement.

"Resveratrol is active in much lower doses than previously thought and mimics a significant fraction of the profile of caloric restriction at the gene expression levels," co-senior author Tomas Prolla, a professor of genetics at the University of Wisconsin -Madison, said in a prepared statement.

The researchers found that resveratrol affected age-related gene expression changes in the heart tissue of mice. The study was published online this week in the Public Library of Science One.

"There must be a few master biochemical pathways activated in response to caloric restriction, which in turn activate many other pathways. And resveratrol seems to activate some of these master pathways as well," Prolla said. DSM Nutritional Products of Switzerland.

More Amazing Resveratrol Research

Scientists around the world have been investigating polyphenolic compounds such as Resveratrol and have shown in laboratory studies that these compounds can improve health and well-being.
Public health agencies such as the National Institutes of Health (NIH), the National Cancer Institute (NCI), the National Institute on Aging(NIA) as well as the United States Department of Agriculture (USDA) have reviewed and studied the potential lifestyle benefits of phenolic compounds.
The National Institutes of Health (NIH) spent over $2.4 billion in 2007 alone to further the scientific understanding of the processes of aging. Towards this end, the National Institute on Aging (NIA) has taken the lead to further the understanding of aging and supports some of the laboratory research on Resveratrol and improved health.
A landmark laboratory study from Harvard Medical School and published in Nature in 2006 suggests that Resveratrol improves energy balance and may protect against cellular aging processes in mice.
Later this study data was converted into a human dose equivalent and published by a research team in a 2007 online and 2008 print journal issue of the Federation of American Societies for Experimental Biology (FASEB).
More recent studies published this year in PLoS ONE, June 2008 and Cell Metabolism, August 2008 indirectly confirm the potential positive effects and intake levels as well.
Specifically, researchers from the National Institute on Aging and other institutions published in the 2008 issue of Cell Metabolism data confirming that Resveratrol may mimic, in laboratory studies, almost all of the effects of dietary or calorie restriction. This process may activate genetic regulators of cellular longevity pathways, which may have positive effects on cellular health and metabolism.

References:

PubMed, a service of the National Library of Medicine, located at the National Institutes of Health, visit at http://www.ncbi.nlm.nih.gov/pubmed/.
National Institutes of Health at http://health.nih.gov/ , National Cancer Institute at http://www.cancer.gov/ , National Institute on Aging at http://www.nia.nih.gov/ . Department of Agriculture at http://www.ars.usda.gov/main/main.htm.
U.S. Department of Health and Human Services, National Institutes of Health: Estimates of funding for various diseases, conditions, research areas. Table Updated February 2008.
Baur JA, Pearson KJ, Price NL, and Jamieson HA, Sinclair DA et al: Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006 Nov 16; 444(7117):337-42.
Reagan-Shaw S et al: Dose Translation from animal to human studies revisited. The FASEB Journal published online before print as doi: 10.1096/fj.07-9574LSF, October 17, 2007.
Reagan-Shaw S et al: Dose translation from animal to human studies revisited. The FASEB Journal 2008; 22:659-661.
Barger JL et al: A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS ONE, June 2008; 3, 6, 1-10.
Pearson K et al: Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metabolism, August 2008; 8, 1-12.

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